Is Zoloft good for DID (dissociative identity disorder, f.k.a. multiple personalities)?

QUESTION:

Dear Dr. Heller,

Is Zoloft good for this problem?  I just started taking it and I wonder if it will help.

Thank you.

ANSWER:

I've taken care of some DID patients, and every one of them also had the BPD (borderline personality disorder).  If the BPD is present I've found Zoloft to be significantly inferior to Prozac, although it can work for some patients.

While all the principles of treating the BPD continue for those with DID, I have found some additional things can be done...

1. Make sure the Tegretol blood level is therapeutic, preferably in the upper third of normal. 
2. Add Remeron for the PTSD and sleep. 
3. Make them safe.  Having a good dog and an alarm system with motion sensors can make a huge difference.